[A replication-defective adenoviral vaccine harboring the gene encoding human L523S protein, a RNA-binding protein, belongs to the KOC (K homology domain containing protein over-expressed in cancer) family. L523S is normally expressed in early embryonic tissues. However, L523S also was overexpressed in, but not limited to, squamous cell cancers of the lung. Upon transfection, recombinant adenovirus-L523S expresses human L523S, which may stimulate a cytotoxic T-cell (CTL) response against tumor cells expressing L523S. ( NCI )]
UMLS (NCI) C1328161Recombinant Adenovirus-L523S Vaccine
- Pharmacologic Substance
- Immunologic Factor