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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AC ACA ACB ACC ACD ACE ACF ACG ACH ACI ACK ACL ACM ACN ACO ACP ACQ ACR ACS ACT ACU ACV ACY

Acute Myeloid Leukemia-1/Eight-Twenty-One Protein

[In acute myeloid leukemia, the frequent t(8;21)(q22;q22) translocation produces a chimeric AML1/ETO gene. Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation. The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells. (from OMIM 133435 and NCI) ( NCI )]
UMLS (NCI) C1332085
AML-1/ETO
 
Amino Acid, Peptide, or Protein


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