[A recombinant protein with megakarypoiesis stimulating activity. AMG 531 mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TPO-R, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TPO-R stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets. ( NCI )]
UMLS (NCI) C1505595Amgen Megakaryopoiesis Protein 2
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Biologically Active Substance