AF-1

[Encoded by human IFNGR2 Gene (Type II Cytokine Receptor Family), 337-aa 38-kDa (precursor) type I membrane protein Interferon Gamma Receptor Beta Chain is an integral accessory factor subunit of Interferon Gamma Receptor Complex required for signal transduction. Ser/Thr phosphorylated IFN Gamma Receptor activates macrophages in innate immune responses to viral infection and host defenses. Ligand-bound receptor activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain. Containing 2 fibronectin type III domains, IFNGR2 may interact with GAF, JAK1, and/or JAK2. (NCI) ( NCI )]

UMLS (NCI) C1334196

IFGR2
Interferon Gamma Receptor Accessory Factor-1
Interferon Gamma Receptor Beta Chain
Interferon Gamma Receptor-2
Interferon Gamma Transducer-1