- 1. (1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol
- [A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated. ( NCI )] (UMLS (NCI) C0905598) 1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene;
Seocalcitol =Organic Chemical; Pharmacologic Substance ;
| - 6. [1R-(1alpha,2beta,4beta)-4-[[[2"',3"-anhydro]-O-3,6-dideoxy-alpha-L-erythro-hexopyranos-4-ulos-1-yl-(1-4)-O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-2-ethyl-1,2,3,4,6,11-h
- [An antineoplastic oligosaccharide anthracycline antibiotic isolated from the bacterium Streptomyces galilaeus. Aclacinomycin B intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0889093) Aclacinomycin B;
Aclarubicin B;
=Organic Chemical; Antibiotic |
- 2. RAL Guanine Nucleotide Dissociation Stimulator
- [Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N-terminal RAS-GEF domain and a noncatalytic C-terminal RAS-associating domain. RALGDS interaction as an effector molecule with RAS-like molecules is specific and dependent on RAS activation by GTP. RALGDS stimulates dissociation of GDP from RAS-related RALA and RALB GTPases, allowing GTP binding and GTPase activation. (NCI) ( NCI )] (UMLS (NCI) C0378212) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 7. [1R-(1alpha,2beta,4beta)]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydeo-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino-alpha-L-lyxo-hexopyranosyl)oxy]-
- [An oligosaccharide anthracycline antineoplastic antibiotic isolated form the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. (NCI04) ( NCI )] (UMLS (NCI) C0001143) =Organic Chemical; Pharmacologic Substance
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- 3. RAL Guanine Nucleotide Dissociation Stimulator Gene
- [This gene plays a role in signal transduction and cytoskeletal remodeling. It is also involved in regulation of cell growth. ( NCI )] (UMLS (NCI) C1335588) RALGDS;
RALGDS Gene;
=Gene or Genome ;
| - 8. [2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha)]-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-9,16-dione
- [A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin. Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin. (NCI04) ( NCI )] (UMLS (NCI) C0127527) =Organic Chemical; Pharmacologic Substance ;
|
- 4. RALA
- [Encoded by human RALA Gene (RAS GTPase Family), 206-aa 24-kDa GTP-binding RAS-like RALA Protein interacts with RALBP1 via its effector domain and likely mediates some cell surface transmembrane receptor signaling. (NCI) ( NCI )] (UMLS (NCI) C0765159) RALA Gene Product;
RALA Protein;
RAS Related Protein A;
=Amino Acid, Peptide, or Protein; Enzyme ;
◊ [This gene plays a role in signal transduction and mediates receptor signaling. ( NCI )] (UMLS (NCI) C0812284) RALA Gene; v-ral Simian Leukemia Viral Oncogene Homolog A (Ras related) wt Allele; Gene or Genome | - 9. [2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha)-11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-4(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-2,6-epoxy-2H-naphtha
- [An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0028261) =Organic Chemical; Pharmacologic Substance
|
- 5. RALB
- [RAL proteins share homology and some properties with the RAS proteins. RALB is a GTP-binding protein. (from OMIM 179551 and NCI) ( NCI )] (UMLS (NCI) C0767970) RALB Gene Product;
RALB Protein;
RAS Related Protein B =Amino Acid, Peptide, or Protein; Enzyme ;
◊ [This gene is involved in signal transduction and regulates receptor signaling. ( NCI )] (UMLS (NCI) C0812283) RALB Gene; "v-ral Simian Leukemia Viral Oncogene Homolog B (Ras Related; GTP Binding Protein) Gene" ; Gene or Genome | - 10. [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- [An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors. ( NCI )] (UMLS (NCI) C0039512) =Carbohydrate; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Glucosides;
Unclassified Ingredient Preparations;
=TENIPOSIDE 10 MG/ML;
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