[Ubiquitously expressed as 3 alternative isoforms by human USF2 Gene, nuclear Upstream Stimulatory Factor 2 is a bHLH transcription factor involved in transcription of a variety of cellular genes that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein. USF1/USF2A heterodimer represents most USF binding activity. (NCI) ( NCI )] (UMLS (NCI) C1447047) FOS-Interacting Protein; Major Late Transcription Factor 2; Upstream Stimulatory Factor 2; Upstream Transcription Factor 2; USF2; =Amino Acid, Peptide, or Protein; Biologically Active Substance