- 1. E2(17)KB 2
- [Encoded by human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family), 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2 targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI) ( NCI )] (UMLS (NCI) C1307637) UBC4/5;
UBE2D2;
Ubiquitin Carrier Protein;
Ubiquitin-Conjugating Enzyme E2-17 kDa 2;
Ubiquitin-Conjugating Enzyme E2D 2;
Ubiquitin-Protein Ligase =Amino Acid, Peptide, or Protein; Enzyme | - 2. EKB 569
- [A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. (NCI05) ( NCI )] (UMLS (NCI) C0961045) EKB-569 =Organic Chemical; Pharmacologic Substance
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