hSARA

[Encoded by MADHIP Gene, ubiquitous cytoplasmic SARA contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Alternate isoforms represent full-length (1425-aa, 156-kD) or truncated protein (1210-aa and 762-aa). Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C0761585

MAD (Mothers Against Decapentaplegic, Drosophila) Homolog Interacting Protein, Receptor Activation Anchor
MADH-Interacting Protein
MADHIP
Mothers Against Decapentaplegic Homolog Interacting Protein
Novel Serine Protease
NSP
Receptor Activation Anchor Protein
SARA Protein
SMAD Anchor for Receptor Activation

Amino Acid, Peptide, or Protein
Biologically Active Substance

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