[A synthetic agent derived from trifluoroethoxy-benzamide exhibiting antiarrhythmic and local anesthetic activity. As a class Ic antiarrhythmic that blocks sodium channels, flecainide depresses polarization phase 0 and decreases the induction velocity of the His-Purkinje system. It also decreases phase 4 slope and increases the depolarization threshold. (NCI04) ( NCI )]
UMLS (NCI) C0016229 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CV300] ANTIARRHYTHMICS
Piperidines
Relation/CHD: FLECAINIDE ACETATE