E7389
[A synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. E7389 binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. (NCI04) ( NCI )]
UMLS (NCI) C1328691Halichondrin B Analog
- Organic Chemical
- Pharmacologic Substance
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