Discs Large (Drosophila) Homolog 4

[Widely expressed by human DLG4 Gene (MAGUK Family), 767-aa 85-kD cytoplasmic Presynaptic Density Protein 95 (concentrated at presynaptic junctions), contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. PSD-95 also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. (NCI) ( NCI )]

UMLS (NCI) C0900627

Discs Large Homolog 4
Postsynaptic Density-95
Presynaptic Density Protein 95
PSD-95
Synapse-Associated Protein 90