DNA Topoisomerase III Alpha

[Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1336768

TOP3A
TOPO III Alpha
Topo III-Alpha
Topoisomerase (DNA) III Alpha
Topoisomerase III Alpha
Topoisomerase, DNA, III
Topoisomerase, DNA, III, Alpha