DNA Mismatch Repair Protein MSH2

[DNA Mismatch Repair Protein MSH2, encoded by the MSH2 gene (MUTS family) is a postreplication mismatch repair homologue of mutS (E. coli), which binds to insertion-deletion looped DNA mismatches. MutS homologues have ATPase activity and contain a conserved DNA binding helix-turn-helix domain associated with an adenine nucleotide/magnesium-binding Walker-A motif that may regulate mismatch binding as a molecular switch. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH2 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. MSH2 alteration is associated with DNA instability. (From SWISS-PROT, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1333234

MSH2
MutS Homolog 2

Amino Acid, Peptide, or Protein
Biologically Active Substance

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