DNA Double-Strand Break Repair and V(D)J Recombination Protein XRCC4

[X-Ray Repair Cross Complementing Protein 4, encoded by the XRCC4 gene, functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. XRCC4 functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. XRCC4 is a ubiquitously expressed protein. Alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. (NCI) ( NCI )]

UMLS (NCI) C1337026

DNA Repair Protein XRCC4
X-Ray Repair Cross Complementing Protein 4
X-Ray Repair, Complementing Defective, Repair In Chinese Hamster
XRCC4