Chemokine Receptor HM74
[Expressed in neutrophils, peripheral blood mononuclear cells, and adipose tissue and encoded by human HM74 Gene (GPCR1 Family, Rhodopsin Family), 387-amino acid 44.5-kD integral membrane Chemokine Receptor HM74 is a putative G protein-coupled receptor, containing a 7-transmembrane receptor domain, similar to orphan receptor GPR31, bradykinin receptor B2, and thrombin receptor F2R. HM74 appears to be a nicotinic acid receptor; binding of nicotinic acid to the mouse ortholog PUMA-G or to HM74 results in G protein-mediated decrease in cAMP levels. PUMA-G mediates anti-lipolytic, lipid-lowering effects of nicotinic acid. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1176162G Protein-Coupled Receptor 109B
GPR109B
HM74
HM74 Protein
Putative Chemokine Receptor, GTP-Binding Protein
Putative G Protein-Coupled Receptor HM74
GPR109B
HM74
HM74 Protein
Putative Chemokine Receptor, GTP-Binding Protein
Putative G Protein-Coupled Receptor HM74
- Amino Acid, Peptide, or Protein
- Receptor
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