[Encoded by human CYP11B1 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 CYP11B1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase expressed in adrenal cortex with steroid 11-beta-hydroxylase activity and involved in conversion of progesterone to cortisol. The 18 or 19-hydroxylation of steroids and aromatization of androstendione to estrone have also been ascribed to CYP11B1. CYP11B1 defects cause adrenal hyperplasia type IV (AH-IV). CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI) ( NCI )]
UMLS (NCI) C0038296 - Amino Acid, Peptide, or Protein
- Enzyme
Relation/PAR: Oxygenase