[A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acids glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymononuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus and fluconazole-resistant Candida albicans strains. ( NCI )]
UMLS (NCI) C1144139Human Lactoferrin Peptide hLF1-11
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Biologically Active Substance
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