P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
Proprostasin
[Expressed in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus, and kidney epithelia, human PRSS8 Gene (Peptidase S1 Family) encodes secreted or membrane anchored 343-aa 36-kD (precursor) Serine Protease-8, similar to acrosin, plasma kallikrein, hepsin, and xCAP1 (Xenopus). The proprotein is cleaved (aa 12-13) to produce disulfide-linked light and heavy chains. The C terminal hydrophobic region is cleaved (aa 290-291) during secretion. Likely involved in semen coagulation and liquefaction, PRSS8 is active with trypsin-like specificity on Lys or Arg carboxyl peptide linkages. Prostasin may regulate ENaC. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0257137- Amino Acid, Peptide, or Protein
- Enzyme
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