[A peptide vaccine containing human tumor associated epithelial mucin (MUC1) conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. MUC1 antigen, a membrane bound glycoprotein expressed by most glandular and ductal epithelial cells, is overexpressed as an aberrant or deglycosylated form in various tumors such as breast, prostate and ovarian cancers. MUC1 antigen is conjugated with KLH, an immunostimulant and a hapten carrier, to enhance immune recognition. Vaccination with MUC1-KLH may result in the production of antibodies as well as elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the MUC1 antigen. ( NCI )]
UMLS (NCI) C0879579MUC-1-KLH vaccine
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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