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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
IN INA INB INC IND INE INF ING INH INI INJ INK INL INM INN INO INP INR INS INT INU INV

Interleukin-1 Receptor-Associated Kinase 3

[Expressed in peripheral leukocytes and monocytes by human IRAK3 Gene, 596-aa Interleukin-1 Receptor-Associated Kinase 3 contains an N-terminal death domain and central kinase domain. IRAK3 appears to activate NF-kappa-B via IL1R. IRAK3 interacts with MYD88 and TRAF6 signaling proteins in a manner similar to the other IRAKs. It prevents dissociation of IRAK and IRAK4 from MYD88 and formation of IRAK/TRAF6 complexes. But IRAK3 does not autophosphorylate in the manner of IRAK1. IRAK1, -2, and -3 mediate the TLR2-dependent response to lipopolysaccharide. IRAK3 is induced upon TLR stimulation and negatively regulates TLR signaling. (NCI) ( NCI )]
UMLS (NCI) C1334202
Interleukin-1 Receptor-Associated Kinase M
IRAK3
IRAKM
 
Amino Acid, Peptide, or Protein
Enzyme


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