[Human integrin alpha-V protein (1048 aa, ~116 kD) is encoded by the integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) gene (ITGAV). This type I membrane protein forms a heterodimer with an integrin beta protein (either the beta-1, 3, 5, 6 or 8 polypeptide). The resulting complex binds to the tripeptide R-G-D, an amino acid sequence present in a number of ligands including vitronectin, fibronectin, fibrinogen, and laminin. Ligand binding regulates cell adhesion, growth and migration. ( NCI )]
UMLS (NCI) C0253930 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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