[Similar in function to IRS1 and IRS2; insulin receptor substrate 4 is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. ( NCI )]
UMLS (NCI) C0664773 - Amino Acid, Peptide, or Protein
- Biologically Active Substance