HMG Box Transcription Factor 4

[Decreasingly expressed from crypt to villus by human TCF7L2 Gene (TCF/LEF Family), nuclear DNA-binding HMG box Transcription Factor 7-Like 2, participates in the WNT pathway and maintains epithelial stem cells of the small intestine. Absent CTNNB1, TCF7L2 acts as a repressor. Bound to the CTNNB1 armadillo repeat in a stable complex, TCF7L2 activates transcription from promoters containing the TCF motif (CCTTTGATC). TCF7L2 binds to the MYC promoter in a sequence-specific manner and modulates MYC expression. The TCF7L2 activation domain binds transcriptional coactivator EP300. TLE1, TLE2, TLE3, and TLE4 repress TCF7L2/CTNNB1 mediated transactivation. Constitutive TCF7L2 activation may promote maintenance of the stem cell phenotype and initiate colorectal cancer. TCF7L2/CTNNB1 may control proliferation versus differentiation in intestinal epithelial cells. (NCI) ( NCI )]

UMLS (NCI) C1336781

hTCF4
T-Cell-Specific Transcription Factor 4
TCF4
TCF7L2
Transcription Factor 7-Like 2