[Encoded by human HLA-A (A2 allele) Gene (HLA Family), HLA-A2 Antigen is a 365-aa 41-kD class I alpha heavy chain glycoprotein heterodimerized with 11.6-kD beta-2 microglobulin. HLA-A protein organization includes a signal peptide, extracellular alpha1, 2, and 3 domains (90-aa each), a transmembrane region, and a cytoplasmic tail. Polymorphic alpha1 and 2 domains determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0019733 - Amino Acid, Peptide, or Protein
- Immunologic Factor
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