H2A Histone Family, Member X
[Encoded by human H2AX Gene (H2A Family) and expressed unlinked to replication in G1 and S-phase, 142-aa basal Histone H2AX has a unique conserved C-terminal sequence, QASQEY. NBS1/phospho-H2AX (gamma-H2AX) associate with irradiation-induced and V(D)J-induced DNA double-strand breaks. In pre-thymocytes, NBS1/gamma-H2AX form at RAG1-mediated TCRA V(D)J cleavage sites. NBS1/gamma-H2AX facilitate AID-dependent DNA break repair in G1 cells undergoing Ig heavy-chain constant region class switch recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1172465H2A.X
H2A/X
H2AFX
H2AX
H2AX Histone
Histone H2A.X
Histone H2AX
H2A/X
H2AFX
H2AX
H2AX Histone
Histone H2A.X
Histone H2AX
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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