[A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an adjuvant in chemotherapy. Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells. When co-administered with alkylating agent melphalan, which utilizing amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity. ( NCI )]
UMLS (NCI) C0071561 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Enzyme
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