[A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04) ( NCI )]
UMLS (NCI) C1142995 - Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance