[This protein is a member of the GRB2/Sem5/Drk family. It functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues. ( NCI )]
UMLS (NCI) C0914970GRB2-Related Adaptor Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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