[Widely expressed (mainly nervous tissue) by human NTRK3 Gene (IR Tyr Kinase Family) as alternative isoforms A (839-aa 94-kDa precursor), B (612-aa), C (825-aa), and D (830-aa), Neurotrophic Tyrosine Kinase Receptor Type 3 is a type I membrane receptor for NTF3 containing 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium and the isoforms do not have identical signaling properties. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK3 undergoes ligand-mediated auto-phosphorylation. (NCI) ( NCI )]
UMLS (NCI) C0132300 - Amino Acid, Peptide, or Protein
- Enzyme
- Receptor
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