[TEL protein is a member of the ETS family of transcription factors. It has an HLH motif and an ETS DNA-binding domain. Translocations of the gene produce chimeric proteins in many leukemias of myeloid or lymphoid origins. Leukemogenic translocations often fuse the TEL HLH domain with the tyrosine kinase domain of other genes, such as PDGFRB, NTRK3, and ABL2 or with other transcription factors, such as AML1 and ARNT. (from OMIM 600618 and NCI) ( NCI )]
UMLS (NCI) C0254343 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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