[Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. It is a drug target. Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI) ( NCI )]
UMLS (NCI) C0039667 - Amino Acid, Peptide, or Protein
- Enzyme
Relation/PAR: amine oxidoreductase
Genes, Reporter