[Encoded by constitutive human TIMP2 Gene (TIMP Family), 207-aa 28-kD secreted TIMP-2 protein contains 12 cysteines and 3 conserved tryptophans. Activity dependent on disulfide bonds, TIMP-2 complexes with and inactivates matrix metalloproteinases involved in extracellular matrix degradation and connective tissue remodeling. TIMP family members may possess selective affinities for matrix metalloproteinases and TIMP-2 may play a different role from TIMP-1 or TIMP-3. TIMP-2 inhibits type IV collagenase in a stoichiometric fashion and acts on MMP-1, -2, -3, -7, -8, -9, -10, -13, -14, -15, -16 and -19. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0145946 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Biologically Active Substance
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