[Cyclin-Dependent Kinase Inhibitor 2C, encoded by the CDKN2C gene, is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI) ( NCI )]
UMLS (NCI) C0292198 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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