[Cyclin-Dependent Kinase Inhibitor 3, encoded by the CDKN3 gene, is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI) ( NCI )]
UMLS (NCI) C0249196 - Amino Acid, Peptide, or Protein
- Enzyme
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