[An injectable collagen matrix gel containing the inorganic platinum agent cisplatin and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, cisplatin alkylates guanine nucleosides in DNA, and causes DNA-DNA or DNA-protein cross-linkages, thereby preventing DNA replication and resulting in tumor cell growth inhibition and apoptosis. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of cisplatin into the tumor tissue and reduce dispersion to the surrounding tissues thereby enhancing the local concentration of cisplatin and increasing its anti-tumor activity. Intratumoral injection of cisplatin-E therapeutic implant may potentially increase chemotherapeutic efficacy compared to systemic administration and reduce systemic toxicity and side effects. ( NCI )]
UMLS (NCI) C0677669 
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