[Cell Division Cycle 42, encoded by the CDC42 gene, is a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant transformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI) ( NCI )]
UMLS (NCI) C0082645 - Amino Acid, Peptide, or Protein
- Enzyme
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