[Encoded by human MCM4 Gene (MCM Family), 863-aa 97-kDa DNA Replication Licensing Factor MCM4 is a highly conserved protein that binds to origin recognition complexes, is essential for replication initiation, and prevents over-replication. A stable complex of MCM4, MCM6, and MCM7 associates with MCM2 specifically bound to histone H3. A key component of the pre-replication complex, hexameric MCM2-7 complex is likely involved in formation of replication forks and recruitment of replication factors. MCM2/4/6/7 complex possesses ATP-dependent DNA helicase activity and may initiate replication as a DNA unwinding enzyme. MCM4 phosphorylation by Cyclin/CDK1,2 suppresses helicase activity and chromatin binding, regulating replication. MCM4 is highly phosphorylated in mitotic cells. (NCI) ( NCI )]
UMLS (NCI) C0663296 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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