[Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI) ( NCI )]
UMLS (NCI) C0108855 - Amino Acid, Peptide, or Protein
- Enzyme
home 
Armenian-English 
top