[Cyclin-Dependent Kinase-Like 2, encoded by the CDKL2 gene, is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI) ( NCI )]
UMLS (NCI) C0534157 - Amino Acid, Peptide, or Protein
- Enzyme
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