[Lymphocyte Function-Associated Antigen-3 (LFA-3), encoded by the CD58 gene, is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI) ( NCI )]
UMLS (NCI) C0081942 - Amino Acid, Peptide, or Protein
- Immunologic Factor
- Receptor
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