[Expressed in all hematopoietic lineages by human PTPRJ Gene (PTP Family), 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J is a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI) ( NCI )]
UMLS (NCI) C0289499 - Amino Acid, Peptide, or Protein
- Enzyme
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