[A nitric oxide (NO) donating derivative of aspirin, a non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective as well as potential antitumor activities. The acetylsalicylic acid derivative inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of thromboxanes and prostaglandins respectively. Reduction in prostaglandins is accountable for its anti-inflammatory, anti-pyretic and analgesic effects whereas the reduction in thromboxanes leads to an irreversible inhibition of platelet activity. Nitric oxide exerts protective activity on the gastric mucosa against the damaging effects of the aspirin derivative by modulating the protective effects of prostaglandins. In cancer cells, nitric oxide-releasing acetylsalicylic acid derivative blocks the cell cycle in the G2 phase, reduces cell proliferation and induces apoptosis through non-COX-mediated mechanisms. ( NCI )]
UMLS (NCI) C0531264 - Organic Chemical
- Pharmacologic Substance
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