BAX
[The BAX gene produces at least four proteins by alternate splicing: membrane-bound alpha and cytoplasmic beta, gamma, and delta; all bind and antagonize BCL2, which represses programmed cell death. Pro-apoptotic BAX acts as a partner of BCL2, shows extensive homology with BCL2, and forms homodimers and heterodimers with BCL2. Pro-apoptotic BAX and BAK proteins accelerate opening of the mitochondrial porin channel, VDAC. BAX appears to interact, and cooperate, with the constitutive pro-apoptotic ANT mitochondrial protein within the pore complex to increase mitochondrial permeability, allowing cytochrome C passage and triggering cell death. Expression of BAX is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in BCL2-negative patients. (from OMIM 600040 and NCI) ( NCI )]
UMLS (NCI) C0219474- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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