[HMGA2 is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. The expression of the gene is cell-cycle regulated. It is likely that the HMGA2 protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGA2 binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (Int J Biochem Cell Biol 1998 Jul;30(7):761-6) ( NCI )]
UMLS (NCI) C0122111 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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