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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BC BC- BCA BCC BCD BCE BCG BCH BCL BCN BCO BCP BCR BCS BCT BCX

B Cell Linker Protein

[B-Cell Linker, encoded by the BLNK gene, is essential for normal B-cell development. This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of B-Cell Linker by SYK provides docking sites for these SH2-containing effector molecules that, in turn permits the phosphorylation and/or activation of their respective signaling pathways. Thus, B-Cell Linker represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development. The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL. (From OMIM and NCI) ( NCI )]
UMLS (NCI) C0756331
B-Cell Linker
B-Cell Linker Protein
BLNK
 
Amino Acid, Peptide, or Protein
Immunologic Factor
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