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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AN AN- ANA ANC AND ANE ANG ANH ANI ANK ANN ANO ANP ANS ANT ANU ANV ANX ANY

Anti-MUC-1

[A monoclonal antibody recognizing human mucin, a cell surface antigen encoded by the MUC-1 gene. In normal tissue, mucin exists as heavily glycosylated form, while tumor-associated mucin molecules are underglycosylated. Underglycosylation exposes the normally cryptic tandem peptide repeats in cancer-associated mucin, thereby allows antigen-antibody interaction with MUC-1 antibody. As a result, the MUC-1 antibody inhibits the initiation of the immunosuppressive cascade triggered by mucin, including production and secretion of prostaglandin E2 (PGE2), followed by VEGF induction and suppression of natural killer cell, lymphokine-activated killer cell and cytotoxic T cell activity. ( NCI )]
UMLS (NCI) C1510931
Anti-MUC-1 Monoclonal Antibody
 
Amino Acid, Peptide, or Protein
Immunologic Factor


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