UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AN AN- ANA ANC AND ANE ANG ANH ANI ANK ANN ANO ANP ANS ANT ANU ANV ANX ANY

Anti-CD33 Immunotoxin

[An immunoconjugate of the humanized monoclonal antibody hP67.6 chemically linked to a bacterial toxin, N-acetyl-gamma calicheamicin, by 4-acetylphenylacetic acid, with antileukemic property. The monoclonal antibody portion specifically binds to CD33 antigen, a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells as well as over-expressed on myelogenous leukemia cells. Upon internalization, calicheamicin, an enediyne class antibiotics, is released from the conjugate by hydrolysis, and binds in a sequence specific manner to the minor groove of DNA. Thereby leads to breakage of double-stranded DNA and consequently resulting in cell death. ( NCI )]
UMLS (NCI) C1510923
 
Amino Acid, Peptide, or Protein
Pharmacologic Substance


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