[An immunotoxin comprised of an anti-B4 (CD19) murine monoclonal antibody linked to the modified plant-derived toxin blocked ricin. The antibody portion of anti-B4 blocked ricin immunotoxin binds to B lymphocytes that express CD19; the ricin portion cleaves the N-glycosidic bond between the ribose and adenine base at position 4324 in the B lymphocyte 28S ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis, and cell death. (NCI04) ( NCI )]
UMLS (NCI) C0763109Anti B4-BR
Anti-B4 Blocked Ricin
Anti-B4 Blocked Ricin Immunotoxin
Anti-B4-bR
Monoclonal Antibody Anti-B4 Blocked Ricin
- Pharmacologic Substance
- Immunologic Factor