[A liposome-encapsulated form of the antineoplastic antibiotic annamycin. Annamycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also circumvents multidrug-resistance (MDR) transporters, including p-glycoprotein. Less toxic than annamycin, liposomal annamycin also shows improved antitumor properties compared to its parent compound. (NCI04) ( NCI )]
UMLS (NCI) C0935796 - Organic Chemical
- Pharmacologic Substance
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