Activating Signal Cointegrator-2

[Encoded by human NCOA6 Gene, ubiquitous 2063-aa 250-kDa mono-/homodimeric Nuclear Receptor Coactivator 6 is a general and nuclear receptor transcriptional coactivator of the ASCOM complex containing two LXXLL motifs (the first mediates ligand-dependent interaction with receptor AF2 domains). NCOA6 directly binds prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors, to strongly enhance transcription in a ligand-/AF2-dependent manner. NCOA6 also appears to interact with RNPC2, NCOA1, CRSP3, RBM14, histone acetyltransferases EP300 and CREBBP, methyltransferases NCOA6IP and HRMT1L1/PRMT2, and with basal transcription factors GTF2A and TBP. Phosphorylated by PRKDC, NCOA6 may coactivate expression via chromatin remodeling and interaction with histone acetyltransferases. It may be involved in coactivation of the NF-kappa-B pathway. (NCI) ( NCI )]

UMLS (NCI) C0915178

AIB3
Amplified in Breast Cancer-3 Protein
ASC2
Cancer-Amplified Transcriptional Coactivator ASC-2
NCOA6
NRC
Nuclear Receptor Coactivator 6
Nuclear Receptor Coactivator RAP250
Nuclear Receptor-Activating Protein 250 kDa
Peroxisome Proliferator-Activated Receptor Interacting Protein
PPAR-Interacting Protein
PRIP
RAP250
Thyroid Hormone Receptor Binding Protein
TRBP

Amino Acid, Peptide, or Protein
Biologically Active Substance

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